Isaac Corry was born on 15 May 1753, probably in Newry, son of Edward Corry, MP. He was educated at Trinity College, Dublin.
He was MP for Newry from 1776 and later the last Chancellor of the Exchequer of Ireland before the Act of Union of 1800. This Act was drafted at his country seat at Derrymore House, Bessbrook, Armagh, a thatched cottage orne set in a landscape park designed by John Sutherland.
He died in Dublin on 15 May 1813.